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Neutrophilic-chronic myeloid leukemia: A case report
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Received: ,
Accepted: ,
This article was originally published by Qassim University and was migrated to Scientific Scholar after the change of Publisher.
Abstract
Neutrophilic-chronic myelogenous leukemia (CML-N) is a rare chronic myelogenous leukemia (CML) variant characterized by BCR-ABL1 positive chronic neutrophilia. It has a BCR breakpoint on chromosome 22 between exons 17 and 20 in a region designated as micro-BCR. It is thought to have a more benign course than classical CML. This case report describes a 41-year-old Saudi woman diagnosed with CML-N. The peripheral blood and bone marrow picture for her were dominated by segmented neutrophils and fluorescent in situhybridization was positive for BCR/ABL fusion of t(9;22). Our patient eventually required a stem cell transplant because of imatinib intolerance and bone marrow failure believed to be induced by nilotinib. Key words Neutrophilic-chronic myeloid leukemia (CML-N); Chronic myeloid leukemia (CML); Neutrophilia